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Penn State vs Ohio State College Football Picks: The Penn State vs Ohio State College Football Picks matchup puts first place in the Big-10 on the line with National Title implications on the line. Penn State will be attempting to head home with a win this time around. Penn State has not won a college football picks matchup in Columbus in 30 years!

OnlineSportsHandicapping.com's college football picks tracker reports that early College Football picks and betting is on Penn State.

OnlineSportsHandicapping.com's college football Opening Line: Penn State -2 , Total 47( ov-105)

The Nittany Lions do have talent this season to compete with the Ohio State Buckeys since quarterback Daryll Clark is the Big Ten's second-highest rated college football passer. Penn State has the seventh best scoring offense in the country, averaging 45.4 points per game and the Nittany Lions also has Evan Royster who leads the Big 10 in yards per carry.

On the other side of the college football pick, Ohio State has started to look like a national title contender this year since Terrelle Pryor took over at quarterback. "When Terrelle is clicking, he can do a little bit of everything," said receiver Brian Robiskie, "He's scary in the open field." It also helps Ohio State that Chris "Beanie" Wells is fully healthy. He has run for 508 yards in four games since his return from injury.

Penn State has lost 10 straight games on the road to teams ranked in the Top 25. On the other side, Ohio State has won 12 of its last 13 conference home games against ranked opponents. Here are more College Football betting stats for Saturday's game. The Nittany Lions are 6-1-1 ATS in their last 8 games overall. The Nittany Lions are 4-1-1 ATS in their last 6 road games. The Nittany Lions are 10-4-2 ATS in their last 16 games in October. The Nittany Lions are 2-5-1 ATS in their last 8 conference games. The Nittany Lions are 0-6 ATS in their last 6 meetings at Ohio State.

Current college football betting line: Penn State -2(-110) 46( ov-110)

The Buckeyes are 8-2 ATS in their last 10 games in October. The Buckeyes are 19-7 ATS in their last 26 conference games. The Buckeyes are 2-6 ATS in their last 8 games overall. The Buckeyes are 0-5 ATS in their last 5 home games. The home team is 9-1 ATS in the last 10 meetings between the two teams.

The Over is 4-1 in the Nittany Lions last 5 conference games. The Over is 5-2 in the Nittany Lions last 7 games overall. The Under is 8-3 in the Buckeyes last 11 games in October. The Under is 5-2 in the Buckeyes last 7 games overall. The Under is 4-1 in the last 5 meetings at Ohio State between the two teams.
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